Advanced strategies for improving the analytical performance of Pt-based nonenzymatic electrochemical glucose sensors: a minireview

Abstract

Enormous demands for blood sugar management, food and pharmaceutical quality control, bioprocess monitoring, and environmental pollution inspection have encouraged the fabrication of high-performance sensing platforms for the detection of glucose in various matrices. In comparison with traditional enzyme-based analytical devices, nonenzymatic electrochemical glucose sensors have attracted special interest and the attention of analysts in the past decade due to their unique advantages; however, the underlying drawbacks of detection performance still seriously restrict their commercial development and large-scale application. This minireview clarifies the intrinsic bottlenecks of glucose amperometric analysis on Pt-based enzymeless interfaces, and emphasis is placed on discussing the advanced strategies utilized to enhance the analytical properties of Pt-based enzyme-free electrochemical glucose sensors.