Issue 2, 2016

Fluorescent turn-on probes for the detection of fluoride ions in organic solvent and in cells

Abstract

We have successfully developed two coumarin-based fluorescent probes to detect Fβˆ’in vitro. Probe 1 is lipophilic for organic soluted detection. Probe 2 is an amphipathic molecule due to its TBDPS and triphenyl-phosphine groups for both mitochondrial localization and fluoride ion detection. Both of the two probes have good selectivity in Fβˆ’ detection; the detection limit of probe 2 was as low as 670 nM. Probe 2 has good fluorescence enhancement in response to Fβˆ’ in cell imaging. The probes are lowly cytotoxic to cells.

Graphical abstract: Fluorescent turn-on probes for the detection of fluoride ions in organic solvent and in cells

Supplementary files

Article information

Article type
Communication
Submitted
28 Aug 2015
Accepted
03 Dec 2015
First published
07 Dec 2015

Anal. Methods, 2016,8, 245-248

Fluorescent turn-on probes for the detection of fluoride ions in organic solvent and in cells

X. Xu, Y. Chen, L. Wei, W. Mao, F. Lin and X. Zhou, Anal. Methods, 2016, 8, 245 DOI: 10.1039/C5AY02267C

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