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Issue 3, 2016
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Photo-induced chemistry for the design of oligonucleotide conjugates and surfaces

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Abstract

A photocaged diene is introduced at the 5′-end of oligonucleotides using the H-phosphonate approach. The photoenol-functionalized DNA is subsequently employed for the conjugation to a protein and the spatially controlled immobilization onto surfaces using a light-induced Diels–Alder cycloaddition. Fully functional protein–DNA conjugates and patterned DNA surfaces are obtained under mild irradiation conditions.

Graphical abstract: Photo-induced chemistry for the design of oligonucleotide conjugates and surfaces

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Publication details

The article was received on 22 Oct 2015, accepted on 01 Dec 2015 and first published on 01 Dec 2015


Article type: Paper
DOI: 10.1039/C5TB02207J
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Citation: J. Mater. Chem. B, 2016,4, 442-449
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    Photo-induced chemistry for the design of oligonucleotide conjugates and surfaces

    A. Vigovskaya, D. Abt, I. Ahmed, C. M. Niemeyer, C. Barner-Kowollik and L. Fruk, J. Mater. Chem. B, 2016, 4, 442
    DOI: 10.1039/C5TB02207J

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