Jump to main content
Jump to site search

Issue 43, 2015
Previous Article Next Article

Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration

Author affiliations

Abstract

In this work, a novel composite scaffold was constructed by combining mesoporous bioactive glass (MBG) and calcium phosphate cement (CPC) materials using a simple centrifugal embedding approach. Furthermore, recombinant human bone morphogenetic protein-2 (rhBMP-2) was facilely incorporated into this scaffold through a freeze-drying process. It is found that the resultant scaffold not only presents a hierarchical pore structure (interconnected pores of around 200 μm and 2–10 μm) and a sufficient compressive strength (up to 1.4 MPa), but also exhibits excellent drug delivery properties, presenting sustained release of rhBMP-2 for over 7 d. In order to evaluate the osteogenetic capacity of the rhBMP-2 loaded MBG/CPC scaffold, in vitro cell culture with bone marrow stromal cells (BMSCs) was conducted. Notably, this composite scaffold presents a favorable effect on the proliferation and osteogenetic differentiation of BMSCs. Furthermore, in vivo bone tissue regeneration was conducted using a rabbit radius defect model. It is demonstrated that the incorporation of rhBMP-2 can induce a significant improvement of osteogenetic efficiency, especially in the early stage. Moreover, better biodegradability was obtained in the rhBMP-2 loaded MBG/CPC scaffold compared to the others. Therefore, it is anticipated that the rhBMP-2 loaded MBG/CPC scaffold is of great potential in the field of rapid bone tissue regeneration.

Graphical abstract: Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Jul 2015, accepted on 20 Sep 2015 and first published on 21 Sep 2015


Article type: Paper
DOI: 10.1039/C5TB01423A
Author version
available:
Download author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 8558-8566

  •   Request permissions

    Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration

    N. Li, C. Jiang, X. Zhang, X. Gu, J. Zhang, Y. Yuan, C. Liu, J. Shi, J. Wang and Y. Li, J. Mater. Chem. B, 2015, 3, 8558
    DOI: 10.1039/C5TB01423A

Search articles by author

Spotlight

Advertisements