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Issue 42, 2015
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Zwitterionic amphiphile coated magnetofluorescent nanoparticles – synthesis, characterization and tumor cell targeting

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Abstract

Magnetofluorescent nanoparticles (MFNPs) have recently attracted significant research interests due to their potential application in biological manipulation and imaging. In this work, through a simple and fast self-assembling process, we first report the preparation of zwitterionic MFNPs (ZW-MFNPs) in the form of micelles using our newly synthesized zwitterionic amphiphiles, CuInS2/ZnS quantum dots, and MnFe2O4 magnetic nanoparticles. ZW-MFNPs integrate both MnFe2O4 magnetic nanoparticles and CuInS2/ZnS quantum dots in their hydrophobic cores and zwitterionic groups such as carboxybetaine and sulfobetaine on their hydrophilic shells. ZW-MFNPs possess dual imaging properties, high (Mn + Fe) recovery, excellent stability in aqueous solutions with a wide pH/ionic-strength range and physiological media, minimal cytotoxicity, and specific targeting to brain tumor cells after bioconjugation with chlorotoxin. The unique characteristics of ZW-MFNPs may open an avenue for these particles to be employed in broad biomedical applications.

Graphical abstract: Zwitterionic amphiphile coated magnetofluorescent nanoparticles – synthesis, characterization and tumor cell targeting

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Publication details

The article was received on 10 Jun 2015, accepted on 14 Sep 2015 and first published on 14 Sep 2015


Article type: Paper
DOI: 10.1039/C5TB01116G
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Citation: J. Mater. Chem. B, 2015,3, 8328-8336
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    Zwitterionic amphiphile coated magnetofluorescent nanoparticles – synthesis, characterization and tumor cell targeting

    V. G. Demillo and X. Zhu, J. Mater. Chem. B, 2015, 3, 8328
    DOI: 10.1039/C5TB01116G

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