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Issue 27, 2015
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Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

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Abstract

We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein–bisphosphonate conjugate.

Graphical abstract: Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

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Publication details

The article was received on 11 May 2015, accepted on 07 Jun 2015 and first published on 09 Jun 2015


Article type: Paper
DOI: 10.1039/C5TB00893J
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Citation: J. Mater. Chem. B, 2015,3, 5544-5552
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    Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

    R. V. Bell, L. A. Rochford, R. T. M. de Rosales, M. Stevens, J. V. M. Weaver and S. A. F. Bon, J. Mater. Chem. B, 2015, 3, 5544
    DOI: 10.1039/C5TB00893J

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