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Issue 30, 2015
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BSA-coated magnetic nanoparticles for improved therapeutic properties

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Abstract

In recent years, magnetic nanoparticles have been widely investigated due to their potential in biomedical applications. For successful in vivo applications, magnetic nanoparticles must satisfy several requirements such as biocompatibility, invisibility to the immune system, high colloidal stability in biological fluids, and long blood circulation times. In this study, we have developed a formulation in which the magnetic nanoparticles are coated with bovine serum albumin to provide enhanced colloidal stability in biological fluids preserving their magnetic properties. In addition, the nanoparticles carry a chemotherapeutic drug, showing their potential as drug delivery systems. Our results reveal the influence of protein adsorption on the colloidal stability and the dynamical magnetic response of functionalized magnetic nanoparticles. Moreover, cellular internalization and in vitro cytotoxic activity in Panc-1 pancreatic cancer cells reveal enhanced cellular internalization, successful intracellular drug delivery, and efficient anticancer activity.

Graphical abstract: BSA-coated magnetic nanoparticles for improved therapeutic properties

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Publication details

The article was received on 05 May 2015, accepted on 17 Jun 2015 and first published on 17 Jun 2015


Article type: Paper
DOI: 10.1039/C5TB00833F
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Citation: J. Mater. Chem. B, 2015,3, 6239-6247
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    BSA-coated magnetic nanoparticles for improved therapeutic properties

    A. Aires, S. M. Ocampo, D. Cabrera, L. D. L. Cueva, G. Salas, F. J. Teran and A. L. Cortajarena, J. Mater. Chem. B, 2015, 3, 6239
    DOI: 10.1039/C5TB00833F

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