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Issue 37, 2015
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Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

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Abstract

A challenge of X-ray radiation therapy is that high dose X-ray can damage normal cells and cause side effects. This paper describes a new nanoparticle-based method to reduce X-ray dose in radiation therapy by internalization of gold nanoparticles that are modified with cationic molecules into cancer cells. A cationic thiol molecule is synthesized and used to modify gold nanoparticles in a one-step reaction. The modified nanoparticles can penetrate cell membranes at high yield. By bringing radio-sensitized gold nanoparticles closer to nuclei where DNA is stored, the total X-ray dose needed to kill cancer cells has been reduced. The simulation of X-ray–gold nanoparticle interaction also indicates that Auger electrons contribute more than photoelectrons.

Graphical abstract: Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

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Supplementary files

Article information


Submitted
24 Apr 2015
Accepted
17 Aug 2015
First published
19 Aug 2015

J. Mater. Chem. B, 2015,3, 7372-7376
Article type
Paper
Author version available

Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

C. Wang, A. Sun, Y. Qiao, P. Zhang, L. Ma and M. Su, J. Mater. Chem. B, 2015, 3, 7372
DOI: 10.1039/C5TB00766F

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