Jump to main content
Jump to site search

Issue 37, 2015
Previous Article Next Article

Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

Author affiliations

Abstract

A challenge of X-ray radiation therapy is that high dose X-ray can damage normal cells and cause side effects. This paper describes a new nanoparticle-based method to reduce X-ray dose in radiation therapy by internalization of gold nanoparticles that are modified with cationic molecules into cancer cells. A cationic thiol molecule is synthesized and used to modify gold nanoparticles in a one-step reaction. The modified nanoparticles can penetrate cell membranes at high yield. By bringing radio-sensitized gold nanoparticles closer to nuclei where DNA is stored, the total X-ray dose needed to kill cancer cells has been reduced. The simulation of X-ray–gold nanoparticle interaction also indicates that Auger electrons contribute more than photoelectrons.

Graphical abstract: Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Apr 2015, accepted on 17 Aug 2015 and first published on 19 Aug 2015


Article type: Paper
DOI: 10.1039/C5TB00766F
Author version
available:
Download author version (PDF)
J. Mater. Chem. B, 2015,3, 7372-7376

  •   Request permissions

    Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

    C. Wang, A. Sun, Y. Qiao, P. Zhang, L. Ma and M. Su, J. Mater. Chem. B, 2015, 3, 7372
    DOI: 10.1039/C5TB00766F

Search articles by author

Spotlight

Advertisements