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Issue 27, 2015
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Radiolanthanide-loaded agglomerated Fe3O4 nanoparticles for possible use in the treatment of arthritis: formulation, characterization and evaluation in rats

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Abstract

This investigation reports the preparation of agglomerated Fe3O4 nanoparticles and evaluation of its utility as a viable carrier in the preparation of radiolanthanides as potential therapeutic agents for the treatment of arthritis. The material was synthesized by a chemical route and characterized by XRD, FT-IR, SEM, EDX and TEM analysis. The surface of agglomerated particle possessed ion pairs (–O:Na+) after dispersing particles in a NaHCO3 solution at pH = 7 which is conducive for radiolanthanide (*Ln = 90Y, 153Sm, 166Ho, 169Er, 177Lu) loading by replacement of Na+ ions with tripositive radiolanthanide ions. Radiolanthanide-loaded particulates exhibited excellent in vitro stability up to ∼3 half-lives of the respective lanthanide radionuclides when stored in normal saline at 37 °C. The radiochemical purities of the loaded particulates were found to be retained to the extent of >70% after 48 h of storage when challenged by a strong chelator DTPA present at a concentration as high as 5 mM, indicating fairly strong chemical association of lanthanides with agglomerated Fe3O4 nanoparticles. Biodistribution studies of 90Y and 166Ho-loaded particulates carried out after intra-articular injection into one of the knee joints of a normal Wistar rat revealed near-complete retention of the radioactive preparations (>98% of the administered radioactivity) within the joint cavity even after 72 h post injection. This was further confirmed by sequential whole-body radio-luminescence imaging. These experimental results are indicative of the potential use of radiolanthanide-loaded agglomerated Fe3O4 nanoparticles for the treatment of arthritis.

Graphical abstract: Radiolanthanide-loaded agglomerated Fe3O4 nanoparticles for possible use in the treatment of arthritis: formulation, characterization and evaluation in rats

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Article information


Submitted
13 Apr 2015
Accepted
26 May 2015
First published
02 Jun 2015

This article is Open Access

J. Mater. Chem. B, 2015,3, 5455-5466
Article type
Paper
Author version available

Radiolanthanide-loaded agglomerated Fe3O4 nanoparticles for possible use in the treatment of arthritis: formulation, characterization and evaluation in rats

S. Chakraborty, K. S. Sharma, A. Rajeswari, K. V. Vimalnath, H. D. Sarma, U. Pandey, Jagannath, R. S. Ningthoujam, R. K. Vatsa and A. Dash, J. Mater. Chem. B, 2015, 3, 5455
DOI: 10.1039/C5TB00677E

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