Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 4, 2015
Previous Article Next Article

Post-infiltration and subsequent photo-crosslinking strategy for layer-by-layer fabrication of stable dendrimers enabling repeated loading and release of hydrophobic molecules

Author affiliations

Abstract

The layer-by-layer (LbL) technique has been intensively investigated as a straightforward method for the incorporation of drug molecules or other bioactive species, enabling retarded release in drug delivery devices, in bioactive interfaces, in tissue engineering, and in regenerative medicine. The preparation of crosslinked LbL multilayers with embedded drug reservoirs for delayed release remains a challenging task, however. In the present study we have developed a method for the simultaneous utilisation of covalent interlayer linkages and drug reservoirs that can hold model drug molecules. A strategy of post-infiltration of photoactive bifunctional small molecules followed by UV irradiation has been employed for crosslinking the LbL multilayers, incorporating poly(amido amine) (PAMAM) molecules, which serve as a drug reservoir. The covalent linkage significantly alters the release profile of the model drug from the multilayers, with retarded release of hydrophobic molecules from a solvent, and enabling the loaded multilayers to withstand rinsing with 75% ethanol, the most commonly used sterilization procedure.

Graphical abstract: Post-infiltration and subsequent photo-crosslinking strategy for layer-by-layer fabrication of stable dendrimers enabling repeated loading and release of hydrophobic molecules

Back to tab navigation

Supplementary files

Article information


Submitted
12 Oct 2014
Accepted
07 Nov 2014
First published
14 Nov 2014

J. Mater. Chem. B, 2015,3, 562-569
Article type
Paper

Post-infiltration and subsequent photo-crosslinking strategy for layer-by-layer fabrication of stable dendrimers enabling repeated loading and release of hydrophobic molecules

Y. Wang, Q. An, Y. Zhou, Y. Niu, R. Akram, Y. Zhang and F. Shi, J. Mater. Chem. B, 2015, 3, 562
DOI: 10.1039/C4TB01688B

Social activity

Search articles by author

Spotlight

Advertisements