Jump to main content
Jump to site search

Issue 8, 2015
Previous Article Next Article

Highly flexible heparin-modified chitosan/graphene oxide hybrid hydrogel as a super bilirubin adsorbent with excellent hemocompatibility

Author affiliations

Abstract

As a pathogenic toxin, bilirubin is generally removed from blood by hemoperfusion for the remission of liver disease or to gain time for patients waiting for liver transplantation. However, the development of bilirubin adsorbents with excellent mechanical properties, adsorption performance and hemocompatibility is still a considerable challenge. In this work, a heparin-modified chitosan/graphene oxide hybrid hydrogel (hep-CS/GH) has been developed for bilirubin adsorption using a lyophilization–neutralization–modification strategy. The as-prepared hybrid hydrogel displayed a unique foam-like porous structure and excellent mechanical flexibility. It was revealed that the incorporation of graphene oxide into the chitosan matrix enhanced both the compressive strength and the Young's modulus of the hybrid hydrogel, as well as its adsorption capacity for bilirubin. The maximum adsorption capacity of hep-CS/GH for bilirubin was 92.59 mg g−1, according to the Langmuir isotherm model. It was demonstrated that hep-CS/GH successfully competed with albumin, and could effectively adsorb bilirubin from a bilirubin-enriched serum. After the hydrogel was modified with heparin, protein adsorption, platelet adhesion and hemolysis were reduced, and the plasma clotting time was prolonged from 4.1 to 23.6 min, indicating the superior hemocompatibility of hep-CS/GH. Therefore, this study may pave the way for improving the performance of the adsorbent in removing blood toxins.

Graphical abstract: Highly flexible heparin-modified chitosan/graphene oxide hybrid hydrogel as a super bilirubin adsorbent with excellent hemocompatibility

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Oct 2014, accepted on 29 Dec 2014 and first published on 02 Jan 2015


Article type: Paper
DOI: 10.1039/C4TB01673D
Author version
available:
Download author version (PDF)
J. Mater. Chem. B, 2015,3, 1646-1654

  •   Request permissions

    Highly flexible heparin-modified chitosan/graphene oxide hybrid hydrogel as a super bilirubin adsorbent with excellent hemocompatibility

    H. Wei, L. Han, Y. Tang, J. Ren, Z. Zhao and L. Jia, J. Mater. Chem. B, 2015, 3, 1646
    DOI: 10.1039/C4TB01673D

Search articles by author

Spotlight

Advertisements