Novel core–shell dextran–hemin crosslinked micelles: synthesis, photo-controlled drug release and excellent (synergetic) antitumor effect

Abstract

In this study, novel core–shell crosslinked dextran–hemin micelles were first successfully synthesized. Hemin grafted to dextran is not only used as a phototriggered switch for the controlled release of loaded 5-fluorouracil (5FU) quickly, but also simultaneously as a photosensitizer for photodynamic therapy under laser irradiation. The prepared micelles exhibit high stability against extensive dilution of solution which can restrain premature drug loss and reduce side effects to human bodies. The micelles possess good biocompatibility as well. More importantly, 5FU-loaded crosslinked dextran–hemin micelles present greater antitumor effect than free 5FU or crosslinked micelles under laser irradiation, indicating the excellent synergetic antitumor effect of hemin with 5FU in the as-prepared micelles. We are convinced that these phototriggered crosslinked micelles combining chemotherapy and photodynamic therapy have tremendous potential for localized cancer treatment.