Synthesis of crosslinked polymeric nanocapsules using catanionic vesicle templates stabilized by compressed CO2

Abstract

The synthesis of polymeric nanocapsules in the approximate diameter range 40–100 nm (TEM/SEM) using catanionic surfactant vesicle templates stabilized by subcritical CO₂ is demonstrated. Near equimolar aqueous solutions of the surfactants sodium dodecyl sulfate (SDS) and dodecyltrimethylammonium bromide (DTAB) experienced immediate vesicle destabilization and precipitation in the absence of CO₂. However, pressurization with CO₂ (5 MPa) dramatically enhanced the stability of the initial vesicles, and enabled swelling of the bilayers with hydrophobic monomers via diffusion loading (loading of monomers into preformed bilayers). Subsequent radical crosslinking polymerization of the monomers n-butyl methacrylate/tert-butyl methacrylate/ethylene glycol dimethacrylate contained within the bilayers was conducted at room temperature using UV-initiation under CO₂ pressure. The hollow structure of the resultant nano-objects was confirmed by successful encapsulation and retention of the dye Nile Blue. It is demonstrated that using this method, polymeric nanocapsules can be successfully prepared using diffusion loading of up to 94 wt% monomer (rel. to surfactant) stabilized by CO₂.