Issue 37, 2015

Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction

Abstract

We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein–nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development.

Graphical abstract: Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction

Supplementary files

Article information

Article type
Communication
Submitted
30 Jul 2015
Accepted
04 Aug 2015
First published
04 Aug 2015

Soft Matter, 2015,11, 7241-7249

Author version available

Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction

S. Siddhanta, I. Barman and C. Narayana, Soft Matter, 2015, 11, 7241 DOI: 10.1039/C5SM01896J

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