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Issue 42, 2015
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Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

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Abstract

We have studied nanoscale diffusion of membrane hydration water in fluid-phase lipid bilayers made of 1,2-dimyristoyl-3-phosphocholine (DMPC) using incoherent quasi-elastic neutron scattering. Dynamics were fit directly in the energy domain using the Fourier transform of a stretched exponential. By using large, 2-dimensional detectors, lateral motions of water molecules and motions perpendicular to the membranes could be studied simultaneously, resulting in 2-dimensional maps of relaxation time, τ, and stretching exponent, β. We present experimental evidence for anomalous (sub-diffusive) and anisotropic diffusion of membrane hydration water molecules over nanometer distances. By combining molecular dynamics and Brownian dynamics simulations, the potential microscopic origins for the anomaly and anisotropy of hydration water were investigated. Bulk water was found to show intrinsic sub-diffusive motion at time scales of several picoseconds, likely related to caging effects. In membrane hydration water, however, the anisotropy of confinement and local dynamical environments leads to an anisotropy of relaxation times and stretched exponents, indicative of anomalous dynamics.

Graphical abstract: Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

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Publication details

The article was received on 11 Jul 2015, accepted on 18 Aug 2015 and first published on 19 Aug 2015


Article type: Paper
DOI: 10.1039/C5SM01713K
Citation: Soft Matter, 2015,11, 8354-8371
  • Open access: Creative Commons BY license
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    Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

    L. Toppozini, F. Roosen-Runge, R. I. Bewley, R. M. Dalgliesh, T. Perring, T. Seydel, H. R. Glyde, V. García Sakai and M. C. Rheinstädter, Soft Matter, 2015, 11, 8354
    DOI: 10.1039/C5SM01713K

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