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Issue 4, 2015
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A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

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Abstract

A novel dynamic covalent gel strategy is reported to immobilize an asymmetric catalyst within the channels of a microfluidic flow reactor. A layer of a catalytically active Mn–salen dynamic covalent imine gel matrix was coated onto a functionalized capillary. Mn–salen active moiety was incorporated into dynamic covalent imine gel matrix via the reaction of a chiral Mn–salen dialdehyde unit with a tetraamine linker. The catalytic activity of the capillary reactor has been demonstrated in enantioselective kinetic resolution of secondary alcohols.

Graphical abstract: A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

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Supplementary files

Article information


Submitted
27 Jan 2015
Accepted
18 Feb 2015
First published
18 Feb 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 2292-2296
Article type
Edge Article

A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

H. Liu, J. Feng, J. Zhang, P. W. Miller, L. Chen and C. Su, Chem. Sci., 2015, 6, 2292
DOI: 10.1039/C5SC00314H

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    [Original citation] - Published by The Royal Society of Chemistry.

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