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Issue 1, 2015
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A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

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Abstract

Agents enabling tumor staging are valuable for cancer surgery. Herein, a targetable sialic acid-armed near-infrared profluorophore (SA-pNIR) is reported for fluorescence guided tumor detection. SA-pNIR consists of a sialic acid entity effective for in vivo tumor targeting and a profluorophore which undergoes lysosomal acidity-triggered fluorogenic isomerization. SA-pNIR displays a number of advantageous biomedical properties in mice, e.g. high tumor-to-normal tissue signal contrast, long-term retention in tumors and low systemic toxicity. In addition, SA-pNIR effectively converts NIR light into cytotoxic heat in cells, suggesting tumor-activatable photothermal therapy. With high performance tumor illumination and lysosome-activatable photothermal properties, SA-pNIR is a promising agent for detection and photothermal ablation of surgically exposed tumors.

Graphical abstract: A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

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Supplementary files

Article information


Submitted
28 Jul 2014
Accepted
19 Sep 2014
First published
25 Sep 2014

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 798-803
Article type
Edge Article
Author version available

A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

X. Wu, M. Yu, B. Lin, H. Xing, J. Han and S. Han, Chem. Sci., 2015, 6, 798
DOI: 10.1039/C4SC02248C

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