Issue 8, 2015

Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions


Nucleic acid three-way junctions (3WJs) play key roles in biological processes such as nucleic acid replication in addition to being implicated as dynamic transient intermediates in trinucleotide repeat sequences. Structural modulation of specific nucleic acid junctions could allow for control of biological processes and disease states at the nucleic acid level. Trinucleotide repeat expansions are associated with several neurodegenerative diseases where dynamic slippage is thought to occur during replication, forming transient 3WJ intermediates with the complementary strand. Here, we report triptycene-based molecules that bind to a d(CAG)·(CTG) repeat using a gel shift assay, fluorescence-quenching and circular dichroism.

Graphical abstract: Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions

Supplementary files

Article information

Article type
Edge Article
02 May 2015
27 May 2015
First published
10 Jun 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 4752-4755

Author version available

Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions

S. A. Barros and D. M. Chenoweth, Chem. Sci., 2015, 6, 4752 DOI: 10.1039/C5SC01595B

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