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Issue 2, 2015
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Metal complexes as potential modulators of inflammatory and autoimmune responses

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Abstract

Over the past few decades, the realm of inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of transition metal complexes, particularly those based on platinum or ruthenium. However, comparatively less attention has been focused on the development of metal complexes for the treatment of inflammatory or autoimmune diseases. Metal complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses. The studies presented here serve to highlight the potential of transition metal complexes in modulating inflammatory or immune pathways in cells.

Graphical abstract: Metal complexes as potential modulators of inflammatory and autoimmune responses

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Publication details

The article was received on 09 Oct 2014, accepted on 07 Nov 2014 and first published on 07 Nov 2014


Article type: Perspective
DOI: 10.1039/C4SC03094J
Chem. Sci., 2015,6, 871-884
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Metal complexes as potential modulators of inflammatory and autoimmune responses

    C. Leung, S. Lin, H. Zhong and D. Ma, Chem. Sci., 2015, 6, 871
    DOI: 10.1039/C4SC03094J

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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