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Issue 65, 2015
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Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands

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Abstract

A selective palladium-catalysed arylation of 2,6-dibromopyridine has been developed by employing N-heterocyclic carbene ligands. Selective mono-arylation was performed in water/acetonitrile solvent system at ambient temperature with catalyst loading of 0.1 mol%. This reaction was also found to proceed smoothly in water although at a slightly elevated temperature of 80 °C. 2,6-Disubstituted and diversely substituted 2,6-pyridines were also obtained in high yields which will be of importance to organic and medicinal chemists.

Graphical abstract: Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands

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Supplementary files

Article information


Submitted
03 Jun 2015
Accepted
10 Jun 2015
First published
10 Jun 2015

RSC Adv., 2015,5, 53073-53085
Article type
Paper

Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands

D. Prajapati, C. Schulzke, M. K. Kindermann and A. R. Kapdi, RSC Adv., 2015, 5, 53073
DOI: 10.1039/C5RA10561G

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