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Issue 83, 2015
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Electrochemiluminescence platform for the detection of C-reactive proteins: application of recombinant antibody technology to cardiac biomarker detection

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Abstract

This work exploits the high-affinity of recombinant antibodies and low background electrochemiluminescence (ECL) for cardiac-biomarker detection. The developed assay is capable of fg mL−1 detection limits as well as the detection of C-Reactive Protein (CRP) over a clinically relevant range. The assay demonstrated robust reproducibility, selectivity and stability while also highlighting a novel platform for detection of cardiac biomarkers at low concentrations.

Graphical abstract: Electrochemiluminescence platform for the detection of C-reactive proteins: application of recombinant antibody technology to cardiac biomarker detection

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Supplementary files

Article information


Submitted
07 May 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

RSC Adv., 2015,5, 67874-67877
Article type
Communication
Author version available

Electrochemiluminescence platform for the detection of C-reactive proteins: application of recombinant antibody technology to cardiac biomarker detection

E. J. O'Reilly, P. J. Conroy, S. Hearty, T. E. Keyes, R. O'Kennedy, R. J. Forster and L. Dennany, RSC Adv., 2015, 5, 67874
DOI: 10.1039/C5RA08450D

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