Pure-shift IMPRESS EXSIDE – Easy measurement of 1H–13C scalar coupling constants with increased sensitivity and resolution

Abstract

The easy-to-interpret and rapid SelEXSIDE NMR experiment for measuring long-range ¹H–¹³C scalar coupling constants ⁿJ_CH is improved with increased sensitivity and resolution by the incorporation of ‘pure-shift’ homonuclear decoupling and IMPRESS-Hadamard encoding, with typical increases in signal-to-noise of over 300% and 400% demonstrated for small molecule examples, and narrower linewidths enabling measurement of smaller coupling constants.