Issue 116, 2015

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Abstract

The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic strategy based on the use of simple glycosides of α-D-mannose or β-D-glucose to modulate the density of biologically active pyrrolizidine and piperidine iminosugars at the gold surface. Exceptionally small and water dispersible gold colloids were obtained by self assembly of thiol ending sugar and novel iminosugar conjugates on the surface of in situ forming gold nanoparticles. The resulting nanostructures were characterized by different techniques. Preliminary screenings demonstrated that the novel nanosized architectures retain their bioactivity and make possible its modulation.

Graphical abstract: Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Supplementary files

Article information

Article type
Paper
Submitted
31 Jul 2015
Accepted
30 Oct 2015
First published
30 Oct 2015
This article is Open Access
Creative Commons BY license

RSC Adv., 2015,5, 95817-95822

Author version available

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

C. Matassini, M. Marradi, F. Cardona, C. Parmeggiani, I. Robina, A. J. Moreno-Vargas, S. Penadés and A. Goti, RSC Adv., 2015, 5, 95817 DOI: 10.1039/C5RA22152H

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