Issue 121, 2015
From the journal:

RSC Advances

A copper-catalyzed domino reaction to construct functionalized indolizinones†

Ben-Quan Hu,ab   Li-Xia Wang,*b   Gang Shen,b   Ya-Lin Tang*b  and  Luo Yang*a  

* Corresponding authors

a Key Laboratory for Environmental Friendly Chemistry and Application, Department of Chemistry, Xiangtan University, Hunan 411105, PR China
E-mail: yangluo@xtu.edu.cn
Fax: +86-731-5829-2251
Tel: +86-731-5829-8351

b Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing 10080, P. R. China
E-mail: wlx8825@iccas.ac.cn, tangyl@iccas.ac.cn
Fax: +86-10-6252-2090
Tel: +86-10-6252-2090

Abstract

An efficient copper-catalyzed domino reaction to 3,8a-disubstituted indolizinones has been firstly developed, and the protocol uses pyridine ketones and terminal alkynes as the starting materials, overriding the isolation of propargylic alcohols.

Graphical abstract: A copper-catalyzed domino reaction to construct functionalized indolizinones

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Article information

DOI
https://doi.org/10.1039/C5RA20119E
Article type
Communication
Submitted
29 Sep 2015
Accepted
05 Nov 2015
First published
09 Nov 2015

RSC Adv., 2015,5, 100097-100101

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A copper-catalyzed domino reaction to construct functionalized indolizinones

B. Hu, L. Wang, G. Shen, Y. Tang and L. Yang, RSC Adv., 2015, 5, 100097 DOI: 10.1039/C5RA20119E

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