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Issue 122, 2015
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Biomedical potential of natural products derived through metagenomic approaches

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Abstract

Microbes are ubiquitous, irrespective of the environment they thrive in, are fascinating source of natural products for several decades. Culturable microbes are an extremely minor fraction when compared to the unculturable part. Many studies have attempted to circumvent this problem since early the 2000s by various culture independent metagenomic approaches. Metagenomics is the ‘study of genetic material recovered directly from microbes’ of environmental samples using a variety of ‘genomic techniques’. Metagenomic approach based discovery resulted in a gamut of natural compounds with unique structural and functional diversity with proven anti-bacterial, anti-fungal, anti-cancer, anti-proliferative and anti-inflammatory properties. This review describes the approaches, biomedical potential of natural product gene clusters and physico-chemical properties of compounds derived using metagenomic approaches.

Graphical abstract: Biomedical potential of natural products derived through metagenomic approaches

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Publication details

The article was received on 02 Oct 2015, accepted on 18 Nov 2015 and first published on 24 Nov 2015


Article type: Review Article
DOI: 10.1039/C5RA20116K
RSC Adv., 2015,5, 101200-101213

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    Biomedical potential of natural products derived through metagenomic approaches

    D. Sanka Loganathachetti and S. Muthuraman, RSC Adv., 2015, 5, 101200
    DOI: 10.1039/C5RA20116K

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