Issue 122, 2015

Biomedical potential of natural products derived through metagenomic approaches

Abstract

Microbes are ubiquitous, irrespective of the environment they thrive in, are fascinating source of natural products for several decades. Culturable microbes are an extremely minor fraction when compared to the unculturable part. Many studies have attempted to circumvent this problem since early the 2000s by various culture independent metagenomic approaches. Metagenomics is the ‘study of genetic material recovered directly from microbes’ of environmental samples using a variety of ‘genomic techniques’. Metagenomic approach based discovery resulted in a gamut of natural compounds with unique structural and functional diversity with proven anti-bacterial, anti-fungal, anti-cancer, anti-proliferative and anti-inflammatory properties. This review describes the approaches, biomedical potential of natural product gene clusters and physico-chemical properties of compounds derived using metagenomic approaches.

Graphical abstract: Biomedical potential of natural products derived through metagenomic approaches

Article information

Article type
Review Article
Submitted
02 Oct 2015
Accepted
18 Nov 2015
First published
24 Nov 2015

RSC Adv., 2015,5, 101200-101213

Biomedical potential of natural products derived through metagenomic approaches

D. Sanka Loganathachetti and S. Muthuraman, RSC Adv., 2015, 5, 101200 DOI: 10.1039/C5RA20116K

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