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Issue 125, 2015
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Sassafras oil, carrot bits and microwaves: green lessons learned from the formal total synthesis of (−)-talampanel

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Abstract

A formal total synthesis of (−)-talampanel (1), a 2,3-benzodiazepine is described. This work was undertaken to utilize greener reaction conditions. Safrole (a renewable source) was converted to (1) in eight steps, including an enantioselective bioreduction using carrots as the key step. Microwave irradiation was also used to perform three reaction steps.

Graphical abstract: Sassafras oil, carrot bits and microwaves: green lessons learned from the formal total synthesis of (−)-talampanel

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Publication details

The article was received on 04 Nov 2015, accepted on 23 Nov 2015 and first published on 26 Nov 2015


Article type: Communication
DOI: 10.1039/C5RA19483K
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RSC Adv., 2015,5, 103563-103565

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    Sassafras oil, carrot bits and microwaves: green lessons learned from the formal total synthesis of (−)-talampanel

    A. T. Omori, C. D. S. de Oliveira, K. T. Andrade and M. G. Capeletto, RSC Adv., 2015, 5, 103563
    DOI: 10.1039/C5RA19483K

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