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Issue 100, 2015

Lead tetraacetate mediated one pot oxidative cleavage and acetylation reaction: an approach to apio and homologated apio pyrimidine nucleosides and their anticancer activity

Author affiliations

Abstract

An efficient and versatile strategy of general applicability towards apio and homologated apio pyrimidines has been delineated. The methodology shows tosylation followed by in situ cyclization and one pot oxidative cleavage and acetylation by Pb(OAc)4 as the key steps. The methodology has been applied to D-ribose and D-mannose derivatives to achieve asymmetric synthesis of apio and homologated apio pyrimidine nucleosides.

Graphical abstract: Lead tetraacetate mediated one pot oxidative cleavage and acetylation reaction: an approach to apio and homologated apio pyrimidine nucleosides and their anticancer activity

Supplementary files

Article information


Submitted
24 Aug 2015
Accepted
18 Sep 2015
First published
21 Sep 2015

RSC Adv., 2015,5, 82450-82459
Article type
Paper

Lead tetraacetate mediated one pot oxidative cleavage and acetylation reaction: an approach to apio and homologated apio pyrimidine nucleosides and their anticancer activity

A. Panda, S. Islam, M. K. Santra and S. Pal, RSC Adv., 2015, 5, 82450 DOI: 10.1039/C5RA19080K

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