Issue 119, 2015

MgBr2-promoted enantioselective aryl addition of ArTi(OiPr)3 to ketones catalyzed by a titanium(iv) catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamine

Abstract

MgBr2-promoted asymmetric addition of ArTi(OiPr)3 to ketones catalyzed by a titanium catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamines is reported, and results showed that the chiral N,N′-sulfonylated cyclohexane-1,2-diamines with electron-withdrawing groups could effectively catalyze asymmetric addition of ArTi(OiPr)3 to ketones to afford desired tertiary alcohols in good yields with good to excellent enantioselectivities of up to 95% ee.

Graphical abstract: MgBr2-promoted enantioselective aryl addition of ArTi(OiPr)3 to ketones catalyzed by a titanium(iv) catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamine

Supplementary files

Article information

Article type
Paper
Submitted
14 Sep 2015
Accepted
05 Nov 2015
First published
10 Nov 2015

RSC Adv., 2015,5, 98391-98398

MgBr2-promoted enantioselective aryl addition of ArTi(OiPr)3 to ketones catalyzed by a titanium(IV) catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamine

C. Shu, S. Zhou and H. Gau, RSC Adv., 2015, 5, 98391 DOI: 10.1039/C5RA18871G

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