Issue 110, 2015
From the journal:

RSC Advances

Palladium-catalyzed intramolecular addition of C–N bond to alkynes: a novel approach to 3-diketoindoles†

Chenglin Wu,‡ab   Fei Zhao,‡c   Shuangjie Shu,b   Jiang Wangb  and  Hong Liu*ab  

* Corresponding authors

a Nano Science and Technology Institute, University of Science and Technology of China, 166 Ren Ai Road, Suzhou 215123, People's Republic of China

b CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China
E-mail: hliu@mail.shcnc.ac.cn

c Sichuan Industrial Institute of Antibiotics, Chengdu University, People's Republic of China

Abstract

Palladium-catalyzed intramolecular addition of C–N bond to alkynes to synthesize 3-diketoindoles via the construction of indole ring with the migration of the α-ketoacyl group has been achieved. This protocol features operational simplicity, high atom economy, broad substrate scope and high yields, thus affording a versatile approach to highly functional 3-diketoindoles.

Graphical abstract: Palladium-catalyzed intramolecular addition of C–N bond to alkynes: a novel approach to 3-diketoindoles

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Article information

DOI
https://doi.org/10.1039/C5RA18813J
Article type
Communication
Submitted
14 Sep 2015
Accepted
12 Oct 2015
First published
13 Oct 2015

RSC Adv., 2015,5, 90396-90399

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Palladium-catalyzed intramolecular addition of C–N bond to alkynes: a novel approach to 3-diketoindoles

C. Wu, F. Zhao, S. Shu, J. Wang and H. Liu, RSC Adv., 2015, 5, 90396 DOI: 10.1039/C5RA18813J

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