Issue 102, 2015

A computationally designed titanium-mediated amination of allylic alcohols for the synthesis of secondary allylamines

Abstract

A computational design was inspired by previous mechanistic studies and the DFT-guided reactions were implemented in the synthesis of secondary allylamines. The participation of titanium imido intermediates facilitated the reaction and the closed transition states in the bond-forming steps rendered exclusive SN2′ substitution products.

Graphical abstract: A computationally designed titanium-mediated amination of allylic alcohols for the synthesis of secondary allylamines

Supplementary files

Article information

Article type
Communication
Submitted
10 Sep 2015
Accepted
23 Sep 2015
First published
24 Sep 2015

RSC Adv., 2015,5, 84284-84289

Author version available

A computationally designed titanium-mediated amination of allylic alcohols for the synthesis of secondary allylamines

Z. Sun, Q. Wang, Y. Xu and Z. Wang, RSC Adv., 2015, 5, 84284 DOI: 10.1039/C5RA18503C

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