Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

M. Borges; S. Yu; A. Laromaine; A. Roig; S. Suárez-García; J. Lorenzo; D. Ruiz-Molina; F. Novio

doi:10.1039/C5RA17661A

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Dual T₁/T₂ MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles†

M. Borges,^a S. Yu,^b A. Laromaine,^b A. Roig,^b S. Suárez-García,^a J. Lorenzo,^c D. Ruiz-Molina^a and F. Novio*^a

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* Corresponding authors

^a ICN2-CSIC – Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, Barcelona 08193, Spain
E-mail: fnovio@cin2.es

^b ICMAB-CSIC – Institut de Ciència de Materials de Barcelona, Consejo Superior de Investigaciones Científicas, Campus de la UAB, 08193 Bellaterra, Barcelona, Spain

^c IBB-UAB – Institut de Biotecnologia i de Biomedicina. Departament de Bioquímica i Biologia Molecular. Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

Abstract

We report a novel hybrid T₁/T₂ dual MRI contrast agent by the encapsulation of SPIONs (T₂ contrast agent) into an iron-based coordination polymer with T₁-weighted signal. This new hybrid material presents improved relaxometry and low cytotoxicity, which make it suitable for its use as contrast agent for MRI.

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Article information

DOI: https://doi.org/10.1039/C5RA17661A
Article type: Communication
Submitted: 31 Aug 2015
Accepted: 07 Oct 2015
First published: 08 Oct 2015
This article is Open Access

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RSC Adv., 2015,5, 86779-86783

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Dual T₁/T₂ MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

M. Borges, S. Yu, A. Laromaine, A. Roig, S. Suárez-García, J. Lorenzo, D. Ruiz-Molina and F. Novio, RSC Adv., 2015, 5, 86779 DOI: 10.1039/C5RA17661A

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