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Issue 109, 2015
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Interaction of chitosan beads with a copper–naproxen metallodrug

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This manuscript reports a novel hybrid system containing a copper-drug entrapped into the chitosan biopolymer. Chitosan beads (CTb) were prepared and investigated for interaction with a copper metallodrug (CuNpx) of the naproxen (HNpx) non-steroidal anti-inflammatory drug. The loading capacity of CTb for CuNpx suggests a sponge-like behavior for copper-drug entrapping at a CuNpx concentration range from 10−4 to 10−2 mol L−1. A novel CTb/CuNpx hybrid material formed by the copper-drug loaded into chitosan beads was prepared and characterized by elemental analysis, scanning electron microscopy, electronic absorption spectroscopy, FTIR spectroscopy, X-ray diffractometry and thermal analysis. The CTb/CuNpx hybrid material was coated with Acrycoat S100, and its behavior in gastric/intestinal pH simulated solutions was investigated to verify potential releasing properties. The coated beads showed a capacity to release naproxen in a sustained release manner for at least 24 h.

Graphical abstract: Interaction of chitosan beads with a copper–naproxen metallodrug

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Publication details

The article was received on 20 Aug 2015, accepted on 10 Oct 2015 and first published on 12 Oct 2015

Article type: Paper
DOI: 10.1039/C5RA16878C
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RSC Adv., 2015,5, 90184-90192

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    Interaction of chitosan beads with a copper–naproxen metallodrug

    D. de J. Martins, Hanif-Ur-Rehman, S. R. Alves Rico, I. de M. Costa, A. C. Pio Santos, R. G. Szszudlowski and D. de Oliveira Silva, RSC Adv., 2015, 5, 90184
    DOI: 10.1039/C5RA16878C

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