Issue 95, 2015

On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity

Abstract

In our continued search for novel trypanocidal compounds, arylamine, chalcone, triazolic, triazole–carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold were prepared; in addition to electrochemical studies, these compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. Among the thirty-eight compounds herein evaluated, six were found to be more potent against trypomastigotes than the standard drug benznidazole, with IC50/24 h values between 52.9 and 89.5 μM.

Graphical abstract: On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2015
Accepted
08 Sep 2015
First published
08 Sep 2015

RSC Adv., 2015,5, 78047-78060

Author version available

On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity

G. A. M. Jardim, W. J. Reis, M. F. Ribeiro, F. M. Ottoni, R. J. Alves, T. L. Silva, M. O. F. Goulart, A. L. Braga, R. F. S. Menna-Barreto, K. Salomão, S. L. de Castro and E. N. da Silva Júnior, RSC Adv., 2015, 5, 78047 DOI: 10.1039/C5RA16213K

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