Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 114, 2015
Previous Article Next Article

Enhanced antibacterial activity of new “composite” biocides with both N-chloramine and quaternary ammonium moieties

Author affiliations

Abstract

In view of the emerging resistance in bacteria against biocides, this work describes a novel combination of two existing biocides in one molecule to improve the bactericidal activity and overcome bacterial resistance. A new series of “composite” biocides combining an amide based N-chloramine with a quaternary ammonium (QA) moiety in one molecule was synthesized and the antibacterial kinetics of each biocide was tested against two clinically retrieved bacteria: methicillin-resistant S. aureus (MRSA) and multi-drug resistant (MDR) P. aeruginosa. The addition of multiple cationic centers into one N-chloramine molecule did not result in enhanced inactivation of bacteria. The bactericidal activity against both microbes increased dramatically when the length of the alkyl chain of QA moiety in these biocides increased to 12 and 14. Covalently bonding N-chloramine with long-chained QA moieties did result in faster kill of MRSA and MDR P. aeruginosa than the formulation with two separate counterparts (N-chloramine and long-chained QA salts). Uptake isotherm curves of the “composite” biocides with long alkyl chain substitution revealed more uptakes of the “composite” biocides by bacteria than the precursor mono-functional biocides (with only QA moieties). An improved antibacterial activity resulted from covalently bonding the two biocides (N-chloramine and long-chained QA salts) into one molecule.

Graphical abstract: Enhanced antibacterial activity of new “composite” biocides with both N-chloramine and quaternary ammonium moieties

Back to tab navigation

Supplementary files

Article information


Submitted
06 Aug 2015
Accepted
23 Oct 2015
First published
23 Oct 2015

RSC Adv., 2015,5, 93877-93887
Article type
Paper
Author version available

Enhanced antibacterial activity of new “composite” biocides with both N-chloramine and quaternary ammonium moieties

C. Ning, L. Li, S. Logsetty, S. Ghanbar, M. Guo, W. Ens and S. Liu, RSC Adv., 2015, 5, 93877
DOI: 10.1039/C5RA15714E

Social activity

Search articles by author

Spotlight

Advertisements