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Issue 118, 2015
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Ene-nucleic acids: a different paradigm to DNA chemistry

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Abstract

Acyclic prochiral nucleic acids such as FNA, UNA, GNA and cyclic chiral TNA are all considered as precursors of DNA and RNA in the chemical etiology of nucleic acids. The chemical reasoning would suggest that unsaturated precursors with constrained flexibility and selectivity based on cis/trans isomers could be the missing link between the prochiral-acyclic and chiral-cyclic structures mentioned above. We find that ene-nucleic acids derived from an isoprenoid skeleton possess requisite flexibility and rigidity while forming stable duplex structures with complementary DNA and RNA.

Graphical abstract: Ene-nucleic acids: a different paradigm to DNA chemistry

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Article information


Submitted
05 Aug 2015
Accepted
29 Oct 2015
First published
03 Nov 2015

RSC Adv., 2015,5, 97824-97830
Article type
Paper
Author version available

Ene-nucleic acids: a different paradigm to DNA chemistry

M. Varada, N. D. Erande and V. A. Kumar, RSC Adv., 2015, 5, 97824
DOI: 10.1039/C5RA15673D

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