Issue 100, 2015

Solid state NMR characterization of zeolite beta based drug formulations containing Ag and sulfadiazine

Abstract

In this study we present a detailed characterization of zeolite beta-based drug formulations with antibacterial properties, containing Ag and sulfadiazine (SD). Solid state NMR spectroscopy (1H, 13C, 29Si, 27Al and 1H–29Si CP-HETCOR experiments) was applied to address some important questions concerning the changes in zeolite structure as a result of the simultaneous presence of both drugs SD and silver sulfadiazine (AgSD). A mechanism for transformation of octahedral defect framework Al sites and encapsulation of the extraframework Al (EFAl) present in the parent beta material into framework tetrahedral species as a result of the drug loading procedure is proposed. The analysis of 1H spectra suggested that an ion exchange process between the zeolite protons and Ag ions occurred upon the solid-state procedure of silver introduction by AgNO3 or AgSD. Suggestions about the location of the drug molecules inside the pores and/or on the crystallite surface are made and the nature of the drug–carrier interactions is discussed. Comparison of 1H spin-lattice (T1) and spin–spin (T2) relaxation times of pure drugs and drug loaded formulations indicate amorphization of the drug incorporated into the zeolite pores.

Graphical abstract: Solid state NMR characterization of zeolite beta based drug formulations containing Ag and sulfadiazine

Supplementary files

Article information

Article type
Paper
Submitted
29 Jul 2015
Accepted
21 Sep 2015
First published
21 Sep 2015

RSC Adv., 2015,5, 81957-81964

Solid state NMR characterization of zeolite beta based drug formulations containing Ag and sulfadiazine

P. Shestakova, C. Martineau, V. Mavrodinova and M. Popova, RSC Adv., 2015, 5, 81957 DOI: 10.1039/C5RA15097C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements