Issue 99, 2015

Tumor cell responses to carbon dots derived from chondroitin sulfate

Abstract

Mass production of carbon dots (CDs) derived from chondroitin sulfate (CS) was developed by the facile hydrothermal approach for the first time. The CS derived CDs (CSCDs) possessed good dispersibility and water solubility, bright blue and green luminescence, and relative pH- and photo-stable properties. Moreover, the multicolor CSCDs could be efficiently uptaken by SAS cells and exhibited low cytotoxicity. Therefore, the responses of human oral squamous cell carcinoma SAS cells to CSCDs were further investigated by evaluating their proliferation and invasion. Compared to CS, CSCDs not only provided higher efficiency for proliferation of SAS cells, and up-regulated expression of matrix metalloproteinases to mimic extracellular matrix secretion, but also portrayed fluorescence for labeling SAS tumor cells. Hence, the multifunctional CSCDs are expected to have potential for biomedical applications.

Graphical abstract: Tumor cell responses to carbon dots derived from chondroitin sulfate

Article information

Article type
Paper
Submitted
23 Jul 2015
Accepted
18 Sep 2015
First published
18 Sep 2015

RSC Adv., 2015,5, 81388-81394

Author version available

Tumor cell responses to carbon dots derived from chondroitin sulfate

S. Wang, B. Wang, F. Bai and X. Ma, RSC Adv., 2015, 5, 81388 DOI: 10.1039/C5RA14585F

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