PhI(OAc)2-promoted metal-free oxidation of 2-oxoaldehydes: a facile one-pot synthesis of cyanoformamides

Zhen Zhan; Xu Cheng; Yang Zheng; Xiaojun Ma; Xiaoyu Wang; Li Hai; Yong Wu

doi:10.1039/C5RA14409D

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PhI(OAc)₂-promoted metal-free oxidation of 2-oxoaldehydes: a facile one-pot synthesis of cyanoformamides†

Zhen Zhan,^a Xu Cheng,^a Yang Zheng,^a Xiaojun Ma,^a Xiaoyu Wang,^a Li Hai*^a and Yong Wu*^a

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* Corresponding authors

^a Key Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China
E-mail: smile@scu.edu.cn, wyong@scu.edu.cn

Abstract

A novel, efficient and environmental method for the conversion of 2-oxoaldehydes into cyanoformamides with iodosobenzene diacetate as oxidant has been developed. The reactions proceeded smoothly at room temperature under metal-free conditions and generated the corresponding products in good to excellent yields.

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Article information

DOI: https://doi.org/10.1039/C5RA14409D
Article type: Communication
Submitted: 21 Jul 2015
Accepted: 23 Sep 2015
First published: 23 Sep 2015

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RSC Adv., 2015,5, 82800-82803

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PhI(OAc)₂-promoted metal-free oxidation of 2-oxoaldehydes: a facile one-pot synthesis of cyanoformamides

Z. Zhan, X. Cheng, Y. Zheng, X. Ma, X. Wang, L. Hai and Y. Wu, RSC Adv., 2015, 5, 82800 DOI: 10.1039/C5RA14409D

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