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Issue 78, 2015
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Glycerol: a more benign and biodegradable promoting medium for catalyst-free one-pot multi-component synthesis of triazolo[1,2-a]indazole-triones

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Abstract

The one-pot three component synthesis of triazolo[1,2-a]indazole-triones was conducted successfully under catalyst-free conditions in glycerol as a benign, nontoxic and biodegradable promoting medium. A broad range of substrates including aromatic aldehydes are condensed with carbonyl compounds possessing a reactive α-methylene group and urazole derivatives. All reactions are completed in short times and the products are obtained in good to excellent yields. Moreover, presented method was applied successfully to the large scale synthesis of title compounds.

Graphical abstract: Glycerol: a more benign and biodegradable promoting medium for catalyst-free one-pot multi-component synthesis of triazolo[1,2-a]indazole-triones

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Publication details

The article was received on 06 Jun 2015, accepted on 17 Jul 2015 and first published on 17 Jul 2015


Article type: Paper
DOI: 10.1039/C5RA13805A
RSC Adv., 2015,5, 63705-63710

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    Glycerol: a more benign and biodegradable promoting medium for catalyst-free one-pot multi-component synthesis of triazolo[1,2-a]indazole-triones

    M. Shekouhy, A. M. Sarvestani, S. Khajeh and A. Khalafi-Nezhad, RSC Adv., 2015, 5, 63705
    DOI: 10.1039/C5RA13805A

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