Iodine catalysed intramolecular C(sp3)–H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Abstract

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp³)–H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.