Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 93, 2015
Previous Article Next Article

Silver-mediated thio-acetoxylation and TFA triggered cyclization of amino disulfides with unactivated alkenes: synthesis of 3-aryl/alkyl-1,4-benzothiazines

Author affiliations

Abstract

A convenient strategy for the synthesis of 3-aryl/alkyl-1,4-benzothiazines has been developed. This reaction proceeds via 1,2-thioacetoxylation of an alkene with silver acetate and acetic acid as an additive, followed by cyclization using TFA. The addition of alkene took place in a regioselective manner, forming exclusively one regioisomer, which was confirmed by a single crystal X-ray study. Various differently substituted alkenes, such as aromatic and aliphatic olefins, were coupled with amino disulfides to form a library of benzothiazine derivatives.

Graphical abstract: Silver-mediated thio-acetoxylation and TFA triggered cyclization of amino disulfides with unactivated alkenes: synthesis of 3-aryl/alkyl-1,4-benzothiazines

Back to tab navigation

Supplementary files

Article information


Submitted
03 Jul 2015
Accepted
25 Aug 2015
First published
25 Aug 2015

RSC Adv., 2015,5, 75881-75888
Article type
Paper

Silver-mediated thio-acetoxylation and TFA triggered cyclization of amino disulfides with unactivated alkenes: synthesis of 3-aryl/alkyl-1,4-benzothiazines

Ch. D. Prasad, A. Verma, Moh. Sattar and S. Kumar, RSC Adv., 2015, 5, 75881
DOI: 10.1039/C5RA12995H

Social activity

Search articles by author

Spotlight

Advertisements