Issue 87, 2015

Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties

Abstract

Four pairs of enantiomeric hypoxanthine analogues (1, 2, 5 and 6), two pairs of enantiomeric adenine analogues (3 and 4), two pyrazines, aspongpyrazines A (7) and B (8), and a pair of glycerides ((+)-9 and (−)-9), along with twenty-eight known substances were isolated from the insect Aspongopus chinensis. The structures of the new natural products were assigned by using spectroscopic and computational methods. Chiral HPLC was used to separate the (−)- and (+)-antipodes of 1–6, and 9. Several of the new, A. chinensis derived natural products were found to promote proliferation of neural stem cells (NSCs) at a concentration of 10 μM.

Graphical abstract: Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties

Supplementary files

Article information

Article type
Paper
Submitted
03 Jul 2015
Accepted
06 Aug 2015
First published
06 Aug 2015

RSC Adv., 2015,5, 70985-70991

Author version available

Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties

L. Di, Y. Shi, Y. Yan, L. Jiang, B. Hou, X. Wang, Z. Zuo, Y. Chen, C. Yang and Y. Cheng, RSC Adv., 2015, 5, 70985 DOI: 10.1039/C5RA12920F

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