Issue 81, 2015
From the journal:

RSC Advances

Ligand-free Cu-catalyzed O-arylation of aliphatic diols†

Yufen Zheng,a   Wenxing Zou,a   Laichun Luo,a   Jiabei Chen,a   Songwen Lina  and  Qi Sun*a  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38, Xueyuan Road, Haidian Distract, Beijing 100191, PR China
E-mail: sunqi@bjmu.edu.cn

Abstract

Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.

Graphical abstract: Ligand-free Cu-catalyzed O-arylation of aliphatic diols

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5RA12529D
Article type
Paper
Submitted
29 Jun 2015
Accepted
27 Jul 2015
First published
27 Jul 2015

RSC Adv., 2015,5, 66104-66108

Author version available

Download author version (PDF)

Permissions

Request permissions

Ligand-free Cu-catalyzed O-arylation of aliphatic diols

Y. Zheng, W. Zou, L. Luo, J. Chen, S. Lin and Q. Sun, RSC Adv., 2015, 5, 66104 DOI: 10.1039/C5RA12529D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements