Metallic copper wire: a simple, clear and reusable catalyst for the CuAAC reaction in supercritical carbon dioxide

Abstract

An efficient protocol for the CuAAC reaction catalyzed by metallic copper wire for the synthesis of 1,4-disubstituted triazoles has been developed in supercritical carbon dioxide (scCO₂) at 50 °C. The protocol could afford the corresponding products in excellent yields with a very easy work-up procedure. The metallic copper wire could be reused for more than 200 runs without decreasing the catalytic efficiency.