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Issue 90, 2015
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Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

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Abstract

A series of novel oxazolidinone derivatives bearing fluoroalkyl-substituted pyrazole as the C-ring structure were designed, synthesized and evaluated for their antibacterial activity against six Gram-positive bacterial pathogens. Most of the target compounds have good antibacterial activity. Especially, compounds 13f, 13i and 13l show excellent activity comparable to linezolid.

Graphical abstract: Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

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Supplementary files

Article information


Submitted
19 Jun 2015
Accepted
21 Aug 2015
First published
21 Aug 2015

RSC Adv., 2015,5, 73660-73669
Article type
Paper
Author version available

Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

L. Yan, J. Wu, H. Chen, S. Zhang, Z. Wang, H. Wang and F. Wu, RSC Adv., 2015, 5, 73660
DOI: 10.1039/C5RA11782H

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