Issue 77, 2015
From the journal:

RSC Advances

Jatrocurcadiones A and B: two novel diterpenoids with an unusual 10,11-seco-premyrsinane skeleton from Jatropha curcas†

Jing-Mei Bao,a   Zhi-You Su,a   Lan-Lan Lou,a   Jian-Yong Zhu,a   Gui-Hua Tang,a   Li-She Gan,b   Xian-Zhang Bua  and  Sheng Yin*a  

* Corresponding authors

a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P. R. China
E-mail: yinsh2@mail.sysu.edu.cn
Fax: +86-20-39943090
Tel: +86-20-39943090

b College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China

Abstract

Two novel diterpenoids, jatrocurcadiones A (1) and B (2), possessing an unusual 10,11-seco-premyrsinane skeleton were isolated from the twigs of Jatropha curcas. Their structures were determined by combined spectroscopic and chemical methods, and the absolute configurations were elucidated by quantum chemical calculations and Rh2(OCOCF3)4-induced CD analysis. Jatrocurcadione A exhibited more potent inhibitory activity (IC50 = 10.0 μM) than the positive control (curcumin, IC50 = 25.0 μM) against thioredoxin reductase (TrxR), a potential target for cancer chemotherapy with redox balance and antioxidant functions.

Graphical abstract: Jatrocurcadiones A and B: two novel diterpenoids with an unusual 10,11-seco-premyrsinane skeleton from Jatropha curcas

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Article information

DOI
https://doi.org/10.1039/C5RA11380F
Article type
Communication
Submitted
15 Jun 2015
Accepted
13 Jul 2015
First published
13 Jul 2015

RSC Adv., 2015,5, 62921-62925

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Jatrocurcadiones A and B: two novel diterpenoids with an unusual 10,11-seco-premyrsinane skeleton from Jatropha curcas

J. Bao, Z. Su, L. Lou, J. Zhu, G. Tang, L. Gan, X. Bu and S. Yin, RSC Adv., 2015, 5, 62921 DOI: 10.1039/C5RA11380F

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