Issue 76, 2015

On-water, catalyst-free and room-temperature construction of 2-aryl-1,3,4-oxadiazole derivatives from 1,1-dichloro-2-nitroethene and hydrazides

Abstract

2-Aryl-1,3,4-oxadiazoles are important functional molecules in many research fields. A green synthetic method for preparation of 2-aryl-1,3,4-oxadiazoles was developed using hydrazides and highly reactive 1,1-dichloro-2-nitroethene. This eco-friendly protocol featured high yields, purification simplicity, water-based reaction medium, energy efficiency and no addition of catalysts.

Graphical abstract: On-water, catalyst-free and room-temperature construction of 2-aryl-1,3,4-oxadiazole derivatives from 1,1-dichloro-2-nitroethene and hydrazides

Supplementary files

Article information

Article type
Paper
Submitted
12 Jun 2015
Accepted
09 Jul 2015
First published
10 Jul 2015

RSC Adv., 2015,5, 61752-61758

Author version available

On-water, catalyst-free and room-temperature construction of 2-aryl-1,3,4-oxadiazole derivatives from 1,1-dichloro-2-nitroethene and hydrazides

F. Zhu, M. Zou, X. Shao and Z. Li, RSC Adv., 2015, 5, 61752 DOI: 10.1039/C5RA11213C

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