A new fluorescence and colorimetric sensor for highly selective and sensitive detection of glucose in 100% water

Abstract

A new naphthalimide derivative containing hexanoic acid and boronate groups was designed and synthesized. The compound displays off/on ratio singles, highly selective and sensitive towards glucose based on a naphthalimide derivative reacting with enzyme generated H₂O₂ in 100% water. The fluorescence intensity is proportional to the concentration of glucose over a range of 0–120 μM (R² = 0.9912), with a limit of detection of 0.3 μM (S/N = 3). Moreover, the fluorescent sensor has been used for determination of glucose in serum with satisfactory results, which further demonstrates its value in practical applications.