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Issue 74, 2015
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Diversity oriented synthesis of 6-nitro- and 6-aminoquinolones and their activity as alkaline phosphatase inhibitors

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Abstract

The novel quinolone derivatives synthesized by cyclization of α,β-ynones with primary amines were shown to be promising TNAP and IAP inhibitors. The mechanism of their formation was studied by the isolation of intermediates.

Graphical abstract: Diversity oriented synthesis of 6-nitro- and 6-aminoquinolones and their activity as alkaline phosphatase inhibitors

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Supplementary files

Article information


Submitted
09 Jun 2015
Accepted
06 Jul 2015
First published
06 Jul 2015

RSC Adv., 2015,5, 60054-60078
Article type
Paper
Author version available

Diversity oriented synthesis of 6-nitro- and 6-aminoquinolones and their activity as alkaline phosphatase inhibitors

M. Miliutina, A. Ivanov, S. A. Ejaz, J. Iqbal, A. Villinger, V. O. Iaroshenko and P. Langer, RSC Adv., 2015, 5, 60054
DOI: 10.1039/C5RA10948E

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