Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 75, 2015
Previous Article Next Article

Bioactive poly(methyl methacrylate) for bone fixation

Author affiliations


Poly(methyl methacrylate) (PMMA) is broadly used for bone fixation. One of the major concerns of using this polymer is the lack of post-implantation integration with the host tissue. We have produced a novel hybrid ceramic–thermoplastic composite manufactured by a sol–gel method via covalent bonding between bioactive glass and PMMA to address this shortcoming. The uniform distribution of bioactive glass promoted the bioactivity of PMMA and substantially improved the biological properties. In this paper, we describe a refinement of the synthesis process of a previously manufactured PMMA–bioactive glass hybrid resulting in significantly more rapid fabrication. Key innovations were the replacement of tetrahydrofuran with ethanol as a more biologically benign reaction solvent, and the addition of sodium bicarbonate as a non-toxic catalyst. Our results showed that the gelation time was decreased 100-fold by increasing the reaction temperature from 25 °C to 70 °C, which also increased the rate of hardening 7-fold. The resulting hybrid monoliths displayed a more condensed structure with an 80% increase in network connectivity and 6-fold more resistance to degradation. These favorable biophysical properties of the new class of hybrids also enhanced the osteoblast adhesion and proliferation compared with the previously developed hybrids. This bioactive glass–PMMA hybrid has great potential to be used as a bone filler.

Graphical abstract: Bioactive poly(methyl methacrylate) for bone fixation

Back to tab navigation

Publication details

The article was received on 12 May 2015, accepted on 06 Jul 2015 and first published on 14 Jul 2015

Article type: Paper
DOI: 10.1039/C5RA08824K
Citation: RSC Adv., 2015,5, 60681-60690

  •   Request permissions

    Bioactive poly(methyl methacrylate) for bone fixation

    R. Ravarian, C. M. Murphy, A. Schindeler, A. Rawal, J. M. Hook and F. Dehghani, RSC Adv., 2015, 5, 60681
    DOI: 10.1039/C5RA08824K

Search articles by author